MOUSE PHENOME PROJECT Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice
نویسندگان
چکیده
Pamela Metten, Karyn L. Best, Andy J. Cameron, Alisha B. Saultz, Jessica M. Zuraw, Chia-Hua Yu, Douglas Wahlsten, and John C. Crabbe Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239; and Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario, Canada N9B 3P4
منابع مشابه
Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice.
Identification of genetic and physiological mechanisms underlying a drug's or mutation's effects on motor performance could be aided by the existence of a simple observation-based rating scale of ataxia for mice. Rating scales were developed to assess ataxia after ethanol (2.75, 3.0, and 3.25 g/kg) in nine inbred mouse strains. Each scale independently rates a single behavior. Raters, blinded t...
متن کاملResponse to ethanol induced ataxia between C57BL/6J and 129X1/SvJ mouse strains using a treadmill based assay.
More sensitive assays of mouse motor ataxia may provide a better understanding of the pathological profile. Treadmill gait analysis using ventral imaging allows for unhindered access to the ambulating mouse. In contrast to genetic mutations or exogenous brain injury, ethanol (EtOH) allows for the detection of dose dependent changes in motor behavior, which can be used to assess an assay's detec...
متن کاملMouse inbred strain differences in ethanol drinking to intoxication.
Recently, we described a simple procedure, Drinking in the Dark (DID), in which C57BL/6J mice self-administer ethanol to a blood ethanol concentration (BEC) above 1 mg/ml. The test consists of replacing the water with 20% ethanol in the home cage for 4 h early during the dark phase of the light/dark cycle. Three experiments were conducted to explore this high ethanol drinking model further. In ...
متن کاملAn analysis of the genetics of alcohol intoxication in inbred mice.
We compared the behaviors of eight inbred mouse strains across 18 variables, using 11 behavioral assays, and gave ethanol (EtOH) as an intoxicant. Genetic influences on behavior and sensitivity to EtOH were pronounced, but strain sensitivities were generally only modestly correlated across tasks. Certain well-correlated clusters of responses suggested that some genes affect similar neurobiologi...
متن کاملP-101: Effects of Ethanol and Strontium on Growth and Development of Two-Cell Arrested Mouse Embryos
Background: Arresting in a certain step of development like two-cell stage could be one of the reasons of infertility. The aim of this study is evaluating the effects of ethanol and strontium on growth and development of two-cell arrested mouse embryos. Materials and Methods: The females were coupled with male following superovulation. Positive vaginal plug mice were killed 48 hours after hCG i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2004